In the comedy film "Cousins" directed by Vysakh, Sam, played by Sethu, sets off on a hilarious adventure to Manipal alongside his cousins Georgy, Pauly, and Tony, portrayed by Kunchacko Boban, Indrajith Sukumaran, and Suraj Venjaramoodu respectively. The motive behind their journey is to help Sam regain his lost memories from a tragic incident that took place six years ago. As they navigate through various comical situations, the cousins bond and uncover unexpected revelations, leading to a heartwarming and laughter-filled tale.